Strategies and tips
19th June 2025

Why building muscle matters on your weight loss journey

When you’re taking weight loss medication like Wegovy or Mounjaro, the focus is often on eating less, managing appetite and watching the number on the scale go down. But there’s another part of the journey that’s just as important – and often overlooked: building and protecting muscle.

Article by CheqUp
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When you’re on weight loss medication, you’re already taking a big and meaningful step toward improving your health. But alongside the scale moving, there’s something else just as important happening behind the scenes – how your body composition is changing.

At CheqUp, we’re not just here to help you lose weight, we’re here to help you lose the right kind of weight. That means protecting and building your muscle mass while targeting excess body fat. Why? Because muscle is key to long-term health, strength and metabolism. And losing too much of it can make it harder to keep the weight off, feel energised and support your body overall.

In the two videos below, Kirsten, one of our CheqUp Health Coaches, shares practical tips on how to protect and build muscle during your weight loss journey. These short clips are packed with simple, science-backed guidance to help you move forward with confidence.

Watch the videos here.

Building strength while losing fat

When your body is in a calorie deficit, whether that’s from changes in appetite, food intake or physical activity, it doesn’t just burn fat but can also start to break down muscle. That’s why it’s so important to focus on keeping the muscle you have and even building more of it where possible.

There are a few key things you can do to protect and build your muscle mass while taking weight loss medication:

Prioritise protein

Protein is your muscle’s best friend. It gives your body the building blocks it needs to maintain and repair muscle tissue, especially when you’re losing weight. Including a good source of protein at every meal can make a big difference – think lean meats, fish, eggs, tofu, beans or protein-rich snacks.

Add resistance training

Strength training, also known as resistance training, is one of the most effective ways to protect your muscle mass and build more of it. It might sound intimidating, but it doesn’t have to be. Using resistance bands, bodyweight exercises like squats or lunges, or lifting light weights at home or the gym are all great places to start. And here’s the bonus: strength training doesn’t just help build muscle. It also helps you burn fat more efficiently, even while you rest.

Walk more than you think

Walking might seem simple, but it counts. It’s a weight-bearing exercise, which means it helps keep your muscles and bones healthy. Regular walks can support your strength goals and help reduce the risk of losing muscle during weight loss.

Check in on your vitamin D and omega-3s

Vitamin D plays a role in muscle function and low levels can make it harder to preserve muscle mass. We often get enough from sunlight during the summer, but in the winter months, your levels might drop, so it’s worth checking them and supplementing if needed.

Omega-3 fatty acids, found in foods like oily fish, flaxseeds and walnuts, may also support muscle maintenance and help reduce inflammation.

No, strength training won’t make you bulky

Let’s clear this up: lifting weights or doing resistance training won’t suddenly make you look bulky. What it will do is help you look leaner, stronger and more toned. Building lean muscle improves how your body burns calories and helps regulate hormones that support your weight loss.

Slow, steady and strong

Muscle matters. It helps you feel strong, supports your metabolism and sets you up for long-term success. Protecting it isn’t about doing everything perfectly – it’s about making small, consistent choices that help your body stay strong while the number on the scale goes down.

At CheqUp, we’re here for the whole journey – not just the start. If you have questions or want more support around strength training, nutrition or how to make these changes work in your life, we’re here to help. You’re not doing this alone.

For more content from Kirsten and other helpful advice see our Facebook page:


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The prescribing of medicines through our website is carried out by CheqUp Health Limited (registered with Care Quality Commission with number 1-17083303713). Our medications are dispensed by Chequp Health Limited.Chequp Health Limited is regulated by the General Pharmaceutical Council (number 9012707) where the Superintendent Pharmacist is Aaron Arman (GPhC number 2216043). You can view our full pharmacy terms and regulatory information, including details on how to contact us or the relevant regulatory bodies, by clicking here.

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